Department of Bioengineering, Hanyang University

2010


  1. Hyesun Hyun, Young-Wook Won, Kyung-Min Kim, Jiyoung Lee, Minhyung Lee*, and Yong-Hee Kim* (2010) Therapeutic effects of a reducible poly (oligo-D-arginine) carrier with the heme oxygenase-1 gene in the treatment of hypoxic-ischemic brain injury. Biomaterials 31: 9128-9134. (*Co-corresponding author).
  2. Jee Seung Han, Hyun Ah Kim, Sanghyun Lee, and Minhyung Lee (2010) VEGF receptor binding peptide-linked high mobility box group-1 box A as a targeting gene carrier for hypoxic endothelial cells. J. Cell. Biochem. 110(5):1094-1100.
  3. Hyunjung Kim, Yun Mi Bae, Hyun Ah Kim, Hyesun Hyun, Gwang Sig Yu, Joon Sig Choi, and Minhyung Lee (2010) Synthesis and characterization of dexamethasone-conjugated linear polyethylenimine as a gene carrier. J. Cell. Biochem. 110: 743-751.
  4. Meng-Lu Liu, Jin Soo Oh, Sung Su An, William A. Pennant, Hyo Jin Kim, So-Jung Gwak, Do Heum Yoon, Keung Nyun Kim, Minhyung Lee, and Yoon Ha (2010) Controlled nonviral gene delivery and expression using stable neural stem cell line transfected with a hypoxia-inducible gene expression system. J. Gene Med. 12: 990-1001.
  5. Hyun Ah Kim, Soyeon Lim, Sung Wan Kim, Ki-Chul Hwang, Minhyung Lee, Sun Hwa Kim, and Donghoon Choi (2010) Hypoxia-inducible vascular endothelial growth factor gene expression using the oxygen dependent degradation domain for ischemic myocardium gene therapy. Pharm. Res. 27: 2075-2084.
  6. Mi Jung Yim, Ju Eun Kim, Cheol-Hee Ahn*, Hyun Ah Kim, Minhyung Lee, and Su Young Chae (2010) Conjugation of histidine derivatives to PEGylated poly(L-lysine-co-L-phenylalanine) copolymer as a non-viral gene carrier. Macromolecular Research 18(6): 545-550.
  7. Hyun Ah Kim and Minhyung Lee (2010) Physiological stress response gene regulation for effective gene therapy. In Targeted delivery of small and macromolecular drugs (Ed: A.S. Narang and R.I. Mahato) CRC press, New York, pp. 587-604.
  8. Jin Soo Oh, Yoon Ha, Sung Su An, Momin Khan, William A. Pennant, Hyo Jin Kim, Do Heum Yoon, Minhyung Lee*, Keung Nyun Kim* (2010) Hypoxia-preconditioned adipose tissue-derived mesenchymal stem cell increase the survival and gene expression of engineered neural stem cells in a spinal cord injury model. Neurosci. Lett. 472: 215-219. (*Co-corresponding author)
  9. Young-Wook Won, Hyun Ah Kim, Minhyung Lee, and Yong-Hee Kim (2010) Reducible poly(oligo-D-arginine) for enhanced gene expression in mouse lung by intratracheal injection. Mol. Ther. 18: 734-742.
  10. Tae-il Kim, Minhyung Lee, and Sung Wan Kim (2010) A guanidinlyated bioreducible polymer with high nuclear localization ability for gene delivery systems. Biomaterials 31: 1798-1804.
  11. Ji Hoon Jeong, Sun Hwa Kim, Minhyung Lee, Won Jong Kim, Tae Gwan Park, Kyung Soo Ko, Sung Wan Kim (2010) Non-viral systemic delivery of Fas siRNA suppresses cyclophosphamide-induced diabetes in NOD mice. J. Control. Release 143: 88-94.
  12. Sung Su An, Hong Lian Jin, Keung Nyun Kim, Hyun Ah Kim, Dong Seok Kim, Joon Cho, Meng-Lu Liu, Jin Soo Oh, Do Heum Yoon, Minhyung Lee, and Yoon Ha (2010) Neuroprotective effect of combined hypoxia-induced VEGF and bone marrow-derived mesenchymal stem cell treatment. Childs Nerv. Syst. 26: 323-331.

2009


  1. Minhyung Lee (2009) Hypoxia targeting gene expression for breast cancer gene therapy. Adv. Drug Deliv. Rev. 61(10): 842-849.
  2. Hyunjung Kim, Hyun Ah Kim, Yun Mi Bae, Joon Sig Choi, and Minhyung Lee (2009) Dexamethasone conjugated polyethylenmine as an anti-apoptotic gene carrier to cardiomyocytes under hypoxia. J. Gene Med. 11(6): 515-522.
  3. Jee Seung Han, Kyunghwa Kim, and Minhyung Lee (2009) Artery wall binding peptide conjugated high mobility group box 1 box A peptide for targeting delivery of nucleic acids. J. Cell. Biochem. 107(1): 163-170.
  4. Hyun Ah Kim, Ram I. Mahato, and Minhyung Lee (2009) Hypoxia-specific gene expression for ischemic disease gene therapy. Adv. Drug Deliv. Rev. 61(7-8): 614-622.
  5. Hyun Ah Kim1, Suyeon Lee1, Jeong-Hyun Park, Sang Hyun Lee, Byung-Wan Lee, Sung Hee Ihm, Tae-il Kim, Sung Wan Kim, Kyung Soo Ko, and Minhyung Lee (2009) Enhanced protection of Ins-1 cells from apoptosis under hypoxia by delivery of DNA encoding secretion signal peptide-linked exendin-4. J. Drug Target. 17(3): 242-248. (1Co-first author).
  6. Hyun Ah Kim, Byung-Wan Lee, Dongchul Kang, Jae Hyeon Kim, Sung Hee Ihm*, and Minhyung Lee* (2009) Delivery of hypoxia inducible VEGF gene to rat islets using polyethylenimine. J. Drug Target. 17(1):1-9. (*Co-corresponding author).
  7. Hyunjung Kim, Hyun Ah Kim, Joon Sig Choi, and Minhyung Lee (2009) Delivery of hypoxia inducible heme oxygenase-1 gene using dexamethasone conjugated polyethylenimine for protection of cardiomyocytes under hypoxia. Bull. Kor. Chem. Soc. 30(4): 897-901.
  8. Minhyung Lee and Ram I. Mahato (2009) Gene regulation for effective gene therapy. Adv. Drug Deliv. Rev. 61(7-8): 487-488.
  9. Byung-Wan Lee, Hee-Young Chae, Tran Thi Ngoc Tuyen, Dongchul Kang, Hyun Ah Kim, Minhyung Lee*, Sung Hee Ihm* (2009) A comparison of non-viral vectors for gene delivery to pancreatic beta-cells: Delivering a hypoxia-inducible vascular endothelial growth factor gene to rat islets. Int. J. Mol. Med. 23(6): 757-762. (*Co-corresponding author).
  10. Jin-Mo Kim, Minhyung Lee, Kil Hwan Kim, Yoon Ha, Jung Kyoung Choi, So Ra Park, Hyeonseon Park, Hyung Chun Park, Cheol-Hee Ahn, Sung Wan Kim, and Byung Hyune Choi (2009) Gene therapy of neural cell injuries in vitro using the hypoxia-inducible GM-CSF expression plasmids and water-soluble lipopolymer (WSLP). J. Control. Release 133(1): 60-67.
  11. Suk H. Bhang, Ju H. Kim, Hee S. Yang, Wan-Geun La, Tae-Jin Lee, Ah-Young Sun, Ga H. Kim, Minhyung Lee, and Byung-Soo Kim (2009) Combined delivery of heme oxygenase-1 gene and fibroblast growth factor-2 protein for therapeutic angiogenesis. Biomaterials 30: 6247-6256.
  12. Honglian Jin, Meng-Lu Liu, Hyun Ah Kim, Minhyung Lee, SungSu An, JinSoo Oh, Joon Cho, Seong Yi, KeungNyun Kim DoHeum Yoon, and Yoon Ha (2009) Role of the oxygen-dependent degradation domain in a hypoxia-inducible gene expression system in vascular endothelial growth factor gene therapy. Spine 34:E952-E958.
  13. Tae-il Kim, Mei Ou, Minhyung Lee, and Sung Wan Kim (2009) Arginine-grafted bioreducible poly(disulfide amine) for highly efficient and non-toxic gene delivery systems. Biomaterials 30(4): 658-664.
  14. James Yockman, Donghoon Choi, Matthew G. Whitten, Chien-Wen Chang, Andrew Kastenmeier, Harold Erickson, Aida Albanil, Minhyung Lee, Sung Wan Kim and David A. Bull (2009) Polymeric gene delivery of ischemia-inducible VEGF significantly attenuates infarct size and apoptosis following myocardial infarct. Gene Ther. 16(1):127-135.
  15. Chang Shin Yoon, Hye Sook Jung, Min Jeong Kwon, Soon Hee Lee, Chan Whan Kim, Mi Kyung Kim, Minhyung Lee and Jeong Hyun Park (2009) Sonoporation of the minicircle-VEGF165 for wound healing of diabetic mice. Pharm. Res. 26(4): 794-801.

2008


  1. Kyunghwa Kim, Jee Seung Han, Jeong Hyun Park, Kyung Soo Ko and Minhyung Lee (2008) Expression and characterization of a recombinant high mobility group box 1 peptide for delivery of nucleic acids. Enzyme Microbial Technol. 43(6): 410-416.
  2. Minhyung Lee, Joon Sig Choi and Kyung Soo Ko (2008) Mitochondria targeting delivery of nucleic acids. Expert Opin. Drug Deliv. 5(8): 879-887.
  3. Chang Shin Yoon, Hye Sook Jung, Tae K. Kim, Min Jeong Kwon, Mi Kyung Kim, Minhyung Lee, Kyung Soo Ko, Byung Doo Rhee and Jeong Hyun Park (2008) Comparison of the efficiency and toxicity of sonoporation with branched polyethylenimine-mediated gene transfection in various cultured cell lines. J. Drug Target. 16(10): 773-779.
  4. Sun-Woong Kang, Hee-Won Lim, Sang-Woo Seo, Oju Jeon, Minhyung Lee, and Byung-Soo Kim (2008) Nanosphere-mediated delivery of vascular endothelial growth factor gene for therapeutic angiogenesis in mouse ischemic limbs. Biomaterials, 29(8): 1109-1117.
  5. Kyunghwa Kim, Jee Seung Han, Hyun Ah Kim and Minhyung Lee (2008) Expression, purification and characterization of TAT-high mobility group box-1A peptide as a carrier of nucleic acids. Biotechnol. Lett., 30(8): 1331-1337.
  6. Suyeon Lee, Kyunghwa Kim, Hyun Ah Kim, Sung Wan Kim, and Minhyung Lee (2008) Augmentation of erythropoietin enhancer-mediated hypoxia inducible gene expression by co-transfection of a plasmid encoding hypoxia-inducible factor 1 alpha for ischemic tissue targeting gene therapy. J. Durg Target., 16: 43-50.
  7. Minhyung Lee, Ji-Kan Ryu, Shuguang Piao, Min Ji Choi, Hyun Ah Kim, Luwei Zhang, Hwa-Yean Shin, Haeng In Jung, In-Hoo Kim, Sung Wan Kim, and Jun Kyu Suh (2008) Efficient gene expression system using the RTP801 promoter in the corpus cavernosum of high cholesterol diet-induced erectile dysfunction rats for gene therapy. J Sexual Med. 5(6): 1355-1364.
  8. Chien-Wen Chang, Lane V. Christensen, Minhyung Lee, and Sung Wan Kim (2008) Efficient expression of vascular endothelial growth factor using minicircle DNA for angiogenic gene therapy. J. Control. Release, 125(2): 155-163.

2007


  1. Yun Mi Bae, Seungah Lee, Seng Ho Kang, Young Tae Kim, Kihoon Nam, Jong Sang Park, Minhyung Lee, and Joog Sig Choi (2007) Dexamethasone-conjugated low molecular weight polyethylenimine as a nucleus targeting lipopolymer gene carrier. Bioconjugate Chem., 18(6): 2029-2036.
  2. Hyun Ah Kim, Kyunghwa Kim, Sung Wan Kim, and Minhyung Lee (2007) Transcriptional and post-translational regulatory system for hypoxia specific gene expression using the erythropoietin enhancer and the oxygen-dependent degradation domain, J. Control. Release, 121(3): 218-224.
  3. Byung Hyune Choi, Yoon Ha, Xian Huang, So Ra Park, Joonho Chung, Dong Keun Hyun, Hyeonseon Park, Hyung Chun Park, Sung Wan Kim, and Minhyung Lee (2007) Hypoxia-inducible expression of vascular endothelial growth factor for the treatment of spinal cord injury in rat model. J. Neurosurg. Spine, 7: 54-60.
  4. Byung Hyune Choi, Yoon Ha, Cheol-Hee Ahn, Xian Huang, Jin-Mo Kim, So Ra Park, Hyeonseon Park, Hyung Chun Park, Sung Wan Kim, Minhyung Lee (2007) A hypoxia-inducible gene expression system using erythropoietin 3' untranslated region for the gene therapy of rat spinal cord injury. Neurosci. Lett. 412: 118-122.
  5. Minhyung Lee (2007) Apoptosis induced by polyethylenimine/DNA complex in polymer mediated gene delivery. Bull. Kor. Chem. Soc. 28: 95-98
  6. Minhyung Lee, Joon Sig Choi, Min Ji Choi, Youngmi Kim Pak, Byoung Doo Rhee, and Kyung Soo Ko (2007) DNA delivery to the mitochondria sites using mitochondrial leader peptide conjugated polyethylenimine. J. Drug Target., 15: 115-122.
  7. Yi-Rac Choi Su Young Chae, Cheol-Hee Ahn, Minhyung Lee, Seungjoon Oh, Youngro Byun, Byoung Doo Rhee, and Kyung Soo Ko (2007) Development of polymeric gene delivery carriers: PEGylated copolymers of L-lysine and L-phenylalanine, J. Drug Target., 15: 391-398.
  8. Oju Jeon, Hee-won Lim, Minhyung Lee, and Byung Soo Kim (2007) Covalent conjugation of nuclear localization signal on biodegradable poly(D,L-lactide-co-glycolide) nanospheres for delivery of plasmid DNA. J. Drug Target. 15: 190-198.
  9. Won Jong Kim, Chien-Wen Chang, Minhyung Lee and Sung Wan Kim (2007) Efficient siRNA delivery using water soluble lipopolymer for anti-angiogenic gene therapy. J. Control. Release, 118: 357-363.
  10. Oju Jeon, Su Jin Song, Minhyung Lee, Sang Woo Seo, Cha Yong Choi, and Byung-Soo Kim (2007) Synthesis and characterization of polyethylenimine-graft-poly(L-lactide-co-glycolide) block copolymers for gene delivery. Key Eng. Mater. 342/343: 521-524.

2006


  1. Joon Sig Choi, Min Ji Choi, Kyung Soo Ko, Youngmi Kim Pak, In Seok Bang, and Minhyung Lee (2006) Low molecular weight polyethylenimine-mitochondrial leader peptide conjugate for DNA delivery to mitochondria. Bull. Kor. Chem. Soc. 27: 1335-1340.
  2. Minhyung Lee, Seungjoon Oh, Cheol-Hee Ahn, Sung Wan Kim, Byoung Doo Rhee and Kyung Soo Ko (2006) An efficient GLP-1 expression system using two step transcription amplification. J. Control. Release 115(3): 316-321.
  3. Minhyung Lee, Donghoon Choi, Min Ji Choi, Ji Hoon Jeong, Won Jong Kim, Seungjoon Oh, Yong-Hee Kim, David A. Bull and Sung Wan Kim (2006) Hypoxia-inducible gene expression system using the erythropoietin enahncer and 3’-untranslated region for the VEGF gene therapy. J. Control. Release 115: 113-119.
  4. Jin-Seong Lee, June Huh, Cheol-Hee Ahrn, Minhyung Lee, and Tae Gwan Park (2006) Synthesis of novel biodegradable cationic dendrimers. Macromolecular Rapid Commun. 27: 1608-1614.
  5. Minhyung Lee, Hyewon Park, Jeehee Youn, Eun Taex Oh, Kyungsoo Ko, Sung Wan Kim, Dongseob Choi, Yongsoo Park (2006) Interleukin-10 plasmid construction and delivery for the prevention of type 1 diabetes. Ann. N. Y. Acad. Sci. 1079: 313-319.
  6. Won Jong Kim, James W. Yockman, Ji Hoon Jeong, Lane V. Christensen, Minhyung Lee, Yong-Hee Kim, Sung Wan Kim (2006) Anti-angiogenic inhibition of tumor growth by systemic delivery of PEI-g-PEG-RGD/pCMV-sFlt-1 complexes in tumor-bearing mice. J. Control. Release 114: 381-388.
  7. Han Chang Kang, Minhyung Lee, and You Han Bae (2006) Polymeric gene delivery vectors. In Nanotechnology in Therapeutics: Current Technology and Applications (Ed: J. Zach Hilt, J. Brook, N.A. Peppas) Horizon Press
  8. Joon Sig Choi, Kyung Soo Ko, Jong Sang Park, Yong Hee Kim, Sung Wan Kim, and Minhyung Lee (2006) Dexamethasone conjugated poly(amidoamine) dendrimer as a gene carrier for efficient nuclear translocation. Int. J. Pharm. 320: 171-178.
  9. Eun Jung Lee, Minhyung Lee, Jong Sang Park, and Joon Sig Choi (2006) Synthesis of 3beta[L-lysinamide-carbamoyl] cholesterol derivatives by solid-phase method and characteristics of complexes with antisense oligodeoxynucleotides, Bull. Kor. Chem. Soc. 27: 1020-1024.
  10. Jeong Hyun Park, Minhyung Lee, and Sung Wan Kim (2006) Non-viral adiponectin gene therapy into obese type 2 diabetic mice ameliorates insulin resistance. J. Control. Release 114: 118-125.
  11. Jung-Bin Kim, Joon Sig Choi, Kihoon Nam, Minhyung Lee, Jong-sang Park and Ja-Kyeong Lee (2006) Enhanced transfection of primary cortical cultures using arginine-grafted PAMAM dendrimer, PAMAM-Arg. J. Control. Release 114: 110-117.
  12. Jung-Bin Kim, Joon Sig Choi, Young-Mi Yu, Kihoon Nam, Chun-Shu Piao, Seung-Woo Kim, Minhyung Lee, Pyung-Lim Han, Jong-sang Park, and Ja-Kyeong Lee (2006) HMGB1, a novel cytokine-like mediator linking acute neuronal death and delayed neuroinflammation in the postischemic brain. J. Neurosci. 26: 6413-6421.
  13. Soo-Jung Lee, Cheol-Hee Ahn, Jung-Hoon Ko, Soo Young Chae, and Minhyung Lee (2006) Syntheis and characterization of poly(L-lysine-co-L-proline) as a non-viral gene delivery vector. Macromolecular Res. 14(2): 129-131.
  14. Ji-Kan Ryu, Chung-Hyun Cho, Hwa-Yean Shin, Sun U. Song, Seung-Min Oh, Minhyung Lee, Shuguang Piao, Jee-Young Han, In-Hoo Kim, Gou Young Koh, and Jun-Kyu Suh (2006) Combined angiopoietin-1 and vascular endothelial growth factor gene transfer restores cavernous angiogenesis and erectile function in a rat model of hypercholesterolemia. Mol. Ther. 13: 705-715.
  15. Minhyung Lee (2006) Apo B-based synthetic peptide-poly(ethylene glycol)-g-polyethylenimine for the receptor-meidated gene delivery. J. Res. Institute Indust. Sci. 54: 155-163.