Department of Bioengineering, Hanyang University

2005


  1. Han Chang Kang, Minhyung Lee, and You Han Bae (2005) Polymeric gene carriers. Crit. Rev. Eukaryot. Gene Expr. 15: 317-342.
  2. Minhyung Lee, Eunsu Lee, Joon Woong Choi, Byung Hyune Choi, So Ra Park, Hyun Seon Park, Hyung Chun Park, Sung Wan Kim, and Yoon Ha* (2005) Ischemic injury-specific gene expression in the rat spinal cord injury model using hypoxia-inducible system. Spine 30: 2729-2734.
  3. Su Young Chae, Sohee Son , Minhyung Lee , Mi-Kyeong Jang , and Jae-Woon Nah* (2005) Deoxycholic acid-conjugated chitosan oligosaccharide nanoparticles for efficient gene carrier. J. Control. Release 109: 330-344.
  4. Joon Sig Choi, and Minhyung Lee* (2005) Effect of dexamethasone preincubation on polymer-ediated gene delivery. Bull. Kor. Chem. Soc. 26(8): 1209-1213.
  5. Ji Hoon Jeong, Minhyung Lee, Won Jong Kim, James W. Yockman, Tae Gwan Park, Yong Hee Kim, and Sung Wan Kim* (2005) Anti-GAD antibody targeted non-viral gene delivery to islet beta cells. J. Control. Release 107(3): 562-570.
  6. Suna Choi, Seungjoon Oh, Minhyung Lee, and Sung Wan Kim* (2005) Glucagon-like peptide-1 plasmid construction and delivery for the treatment of type 2 diabetes. Mol. Ther. 12(5): 885-891.
  7. Minhyung Lee, Ji-Kan Ryu, Seung-Min Oh, Eunsu Lee, Hwa-Yeon Shi, Sun U. Song, Sung Wan Kim, and Jun-Kyu Suh* (2005) Water-soluble lipopolymer as a gene carrier to corpus cavernosum. Int. J. Impot. Res. 17: 326-334.
  8. Wong Jong Kim, James W. Yockman, Minhyung Lee, Ji Hoon Jeong, Yong-Hee Kim and Sung Wan Kim* (2005) Soluble Flt-1 gene delivery using PEI-g-PEG-RGD conjugate for anti-angiogenesis. J. Control. Release 106: 224-234.
  9. Han Chang Kang, Sungwon Kim, Minhyung Lee, and You Han Bae* (2005) Polymeric gene carrier for insulin secreting cells: Poly(L-lysine)-g-sulfonylurea for receptor mediated transfection. J. Control. Release 105: 164-176.
  10. Malavosklish Bikram, Minhyung Lee, Chien-Wen Chang, Margit-Maria Janat-Amsbury, Steven E. Kern, and Sung Wan Kim* (2005) Long-circulating DNA-complexed biodegradable multiblock copolymers for gene delivery: degradation profiles and evidence of dysopsonization. J. Control. Release 103: 221-233.
  11. Young Heui Kim, Jeong Hyun Park, Minhyung Lee, Tae Gwan Park, and Sung Wan Kim* (2005) Polyethylenimine with acid-labile linkages as a biodegradable gene carrier. J. Control. Release 103: 209-219.
  12. Minhyung Lee, and Sung Wan Kim* (2005) Polyethylene glycol conjugated copolymers for plasmid DNA delivery. Pharm. Res. 22: 1-10.
  13. Ji-Kan Ryu, Sun U. Song, Jee-Young Han, Young-Chae Chu, Minhyung Lee, Jun-Sig Kim, Seong-Jin Kim, and Jun-Kyu Suh* (2005) Establishment of penile fibrosis model in a rat using mouse NIH3T3 fibroblasts expression transforming growth factor-1. Biol. of Reprod. 72: 916-921.
  14. Margit Maria Janát-Amsbury, James W. Yockman, Darin Y. Furgeson, Minhyung Lee, Steven Kern, Malavosklish Bikram and Sung Wan Kim* (2005) Local, non-viral IL-12 gene therapy using a water soluble lipopolymer as carrier system combined with systemic paclitaxel for cancer treatment. J. Control. Release 101: 273-285.

2004


  1. Minhyung Lee (2004) Polymeric gene carriers and their applications to diabetes gene therapy. J. Kor. Soc. Endocinol. 19: 463-472.
  2. Minhyung Lee* and Sung Wan Kim (2004) Basic components of plasmid-based gene expression systems. In Biomaterials-based Delivery and Biocompatibility of Protein and Nucleic Acids (Ed: R.I. Mahato) CRC Press, New York, pp. 615-642.
  3. Minhyung Lee, and Sung Wan Kim* (2004) Poly(L-lysine) and copolymers. In Polymeric gene delivery: Principles and applications (Ed: Amiji), CRC Press, New York, 79-95.
  4. Jeoung-Soo Lee, Minhyung Lee, and Sung Wan Kim (2004) Novel potent human FIX plasmid for gene therapy of hemophilia. Pharm. Res. 21(7): 1229-1232.
  5. Margit Maria Janát, James W. Yockman, Darin Y. Furgeson, Minhyung Lee, Steven Kern, and Sung Wan Kim* (2004) Combination of local, non-viral IL-12 gene therapy and systemic paclitaxel treatment in a highly metastatic breast cancer model. Mol. Ther. 9(6): 829-836.
  6. Minhyung Lee, Malavosklish Bikram, Seungjoon Oh, David A. Bull and Sung Wan Kim* (2004) SP1-dependent regulation of the RTP801 promoter under hypoxia condition and its application to hypoxia inducible VEGF plasmid. Pharm Res. 21(5): 736-741.
  7. Minhyung Lee*, Sun U. Song, Ji Kan Ryu, and Jun Kyu Suh (2004) Sp1-mediated transcription of the TIMP-1 promoter. J. Cell. Biochem. 91(6): 1260-1268.
  8. Su Young Chae, Minhyung Lee, Sung Wan Kim, and You Han Bae* (2004) Protection of insulin secreting cells from nitric oxide induced cellular damage by crosslinked hemoglobin. Biomaterials. 25: 843-850.
  9. Malavosklish Bikram, Cheol-Hee Ahn, Su Young Chae, Minhyung Lee, James W. Yockman, and Sung Wan Kim (2004) Biodegradable poly(ethylene glycol)-co-poly(L-lysine)-g-histidine multi-block copolymers as an efficient and safe gene delivery carrier. Macromolecules 37(5): 1903-1916.

2003


  1. David A. Bull*, Stephen H. Bailey, Jeffrey J. Rentz, James S. Zebrack, Minhyung Lee, Sheldon E. Litwin, and Sung Wan Kim (2003) Effect of Terplex/VEGF-165 gene therapy on left ventricular function and structure following myocardial infarction VEGF gene therapy for myocardial infarction. J. Control. Release 93: 175-181.
  2. Minhyung Lee, Kyung Soo Ko, and Sung Wan Kim* (2003) Cytokine gene therapy for the prevention of autoimmune diabetes. In Advances in Biomaterials and Drug Delivery Systems (Eds: G.H. Hsiue, T. Okano, U.Y. Kim, H.W. Sung, N. Yui and K.D. Park), Princeton International Publishing Co., Ltd, Taiwan.
  3. Minhyung Lee, Jeffrey Rentz, Malavosklish Bikram, Sang-oh Han, David A. Bull, and Sung Wan Kim* (2003) Hypoxia inducible VEGF gene delivery to ischemic myocardium using water-soluble lipopolymer. Gene Ther. 10: 1535-1542.
  4. Seungjoon Oh, Minhyung Lee, Kyung Soo Ko, and Sung Wan Kim* (2003) GLP-1 gene delivery for the treatment of type 2 diabetes. Mol. Ther. 7: 478-483.
  5. Minhyung Lee, Kyung Soo Ko, Seungjoon Oh, and Sung Wan Kim* (2003) Prevention of autoimmune insulitis by delivery of a chimeric plasmid encoding interleukin-4 and interleukin-10. J. Control. Release 88: 333-342.
  6. Minhyung Lee, Jeffrey Rentz, Sang-oh Han, David A. Bull, and Sung Wan Kim* (2003) Water soluble lipopolymer as an efficient carrier for gene delivery to myocardium. Gene Ther. 10: 585-593.

2002


  1. Minhyung Lee, and Sung Wan Kim* (2002) Polymeric gene carriers. Pharmaceutical News 9(6):  407-415.
  2. Minhyung Lee, Yong-beom Lim, and Jong-sang Park* (2002) Partial purification and characterization of an 80-kDa transcription factor binding to bHLH motif in the rat p53 promoter. Mol. Biol. Rep. 29: 337-345.
  3. Kyung Soo Ko, Minhyung Lee, and Sung Wan Kim* (2002) Gene therapy for the prevention of autoimmune diabetes. In Pharmaceutical perspectives of nucleic acid-based therapeutics (Eds: R.I. Mahato and S.W. Kim), Taylor & Francis, New York, pp 508-519.
  4. Minhyung Lee, Jae Joon Koh, Sang-oh Han, Kyung Soo Ko, and Sung Wan Kim* (2002) Prevention of autoimmune insulitis by delivery of interleukin-4 plasmid using a soluble and biodegradable polymeric carrier. Pharm. Res. 19: 246-249.

2001


  1. Minhyung Lee, Sang-oh Han, Kyung Soo Ko, Jae Joon Koh, Jong-sang Park, Ji-Won Yoon, and Sung Wan Kim* (2001) Repression of GAD autoantigen expression in pancreas -cell by delivery of antisense plasmid/PEG-g-PLL complex. Mol. Ther. 4: 339-346.
  2. Kyung Soo Ko, Minhyung Lee, Jae Joon Koh, and Sung Wan Kim* (2001) Combined administration of plasmids encoding IL-4 and IL-10 prevents the development of autoimmune diabetes in nonobese diabetic mice. Mol. Ther. 4: 313-316.
  3. Minhyung Lee, Sang-oh Han, Kyung Soo Ko, and Sung Wan Kim* (2001) Cell type specific and glucose responsive expression of interleukin-4 by using insulin promoter and water soluble lipopolymer. J. Control. Release 75: 421-429.
  4. Ram I. Mahato, Minhyung Lee, Sang-oh Han, Anurag Maheshwari, and Sung Wan Kim* (2001) Intratumoral delivery of p2CMVmIL-12 using water-soluble lipopolymers. Mol. Ther. 4: 130-138.
  5. Sunhee Yu, Minhyung Lee, Seungjin Shin, and Jong-sang Park* (2001) Apoptosis induced by progesterone in human ovarian cancer cell line SNU-840. J. Cell. Biochem. 82: 445-451.
  6. Haisun Song, Minhyung Lee, Sunhee Yu, and Jong-sang Park* (2001) Identification of a transcription factor, and 80-kDa protein that interacts with the HLH recognition motif of the rat p53 promoter. Biochem. Cell Biol. 79: 153-158.
  7. Minhyung Lee, Jae-Woon Nah, Youngmin Kwon, Jae Joon Koh, Kyung Soo Ko, and Sung Wan Kim* (2001) Water-soluble and low molecular weight chitosan-based plasmid DNA delivery. Pharm. Res. 18: 427-431.
  8. Young Jin Kim, Suna Choi, Jae Joon Koh, Minhyung Lee, Kyung Soo Ko, and Sung Wan Kim* (2001) Controlled release of insulin from injectable biodegradable triblock copolymer. Pharm. Res. 18: 548-550.
  9. Minhyung Lee, Sunhee Yu, Young-sam Lee, and Jong-sang Park* (2001) Characterization of nuclear factors binding to AT-rich element in the rat p53 promoter. J. Cell. Biochem. 80: 580-588.