Department of Bioengineering, Hanyang University




허혈성 뇌졸중 유전자 및 단백질 치료 연구
유전자 전달체 개발


  1. Jaewon Lee, Jungju Oh, Eun-song Lee, Young-Pil Kim, and Minhyung Lee (2019) Conjugation of prostate cancer-specific aptamers to polyethylene glycol-grafted polyethylenimine for enhanced gene delivery to prostate cancer cells. J. Ind. Eng. Chem. In press.
  2. Gyeungyun Kim, Chunxian Piao, Jungju Oh, Minhyung Lee (2018) Combined delivery of cur cumin and the heme oxygenate-1 gene using cholesterol-conjugated polyamidoamine for anti-inflammatory therapy in acute lung injury. Phytomed. 56:165-174.
  3. Dahee Lee, Eunji Choi, Jaewon Lee, Jungju Oh, Seonyeong Lee, Minhyung Lee (2018) RAGE-binding peptide-conjugated polyethylenimine as a dual-functional carrier: A RAGE-mediated gene carrier and an anti-angiogenic reagent. J. Ind. Eng. Chem. 67:284-292.
  4. Gyeungyun Kim, Chunxian Piao, Jungju Oh, and Minhyung Lee (2018) Self-assembled polymeric micelles for combined delivery of anti-inflammatory gene and drug to the lungs by inhalation. Nanoscale. 18: 8503-8514.
  5. Eunji Choi, Jungju Oh, Dahee Lee, Jaewon Lee, Xiaonan Tan, Minhyung Kim, Gyeungyun Kim, Chunxian Piao, and Minhyung Lee (2018) A ternary-complex of a suicide gene, a RAGE-binding peptide, and polyethylenimine as a gene delivery system with anti-tumor and anti-angiogenic dual effects in glioblastoma. J. Control. Release 279: 40-52.
  6. Xiaonan Tan, Gyeungyun Kim, Dahee Lee, Jungju Oh, Minkyung Kim, Chunxian Piao, Jaewon Lee, Min Sang Lee, Ji Hoon Jeong, and Minhyung Lee (2018) A curcumin-loaded polymeric micelle as a carrier of a microRNA-21 antisense-oligonucleotide for enhanced anti-tumor effects in a glioblastoma animal model. Biomater. Sci. 6: 407-417.
  7. Jungju Oh, Min Sang Lee, Ji Hoon Jeong*, and Minhyung Lee* (2017) Deoxycholic Acid-Conjugated Polyethylenimine for Delivery of Heme Oxygenase-1 Gene in Rat Ischemic Stroke Model. J. Pharm. Sci. 106(12): 3524-3532.
  8. Minhyung Lee, Min Jun Kim, Jungju Oh, Chunxian Piao, Young-Woo Park, and Dong Yun Lee (2017) Gene delivery to pancreatic islets for effective transplantation in diabetic animal. J. Ind. Eng. Chem. 56: 45-54.
  9. Eunji Choi, Jaesik Han, Xiaonan Tan, Jungju Oh, Dahee Lee, Taiyoun Rhim*, and Minhyung Lee* (2017) Combined delivery of temozolomide and the thymidine kinase gene for treatment of glioblastoma. J. Drug Target. 25(2): 156-162.
  10. Binna Oh, Hojung Song, Dahee Lee, Jungju Oh, Gyeungyun Kim, Sung-Hee Ihm*, and Minhyung Lee* (2016) Anti-cancer effect of R3V6 peptide-mediated delivery of an anti-microRNA-21 antisense-oligodeoxynucleotide in a glioblastoma animal model. J. Drug Target. 25(2): 132-139.
  11. Manbok Choi, Jungju Oh, Taiyoun Rhim*, and Minhyung Lee* (2016) Delivery of hypoxia-inducible heme oxygenase-1 gene for site-specific gene therapy in the ischemic stroke animal model. Pharm. Res. 33(9): 2250-2258.
  12. Jaesik Han, Jungju Oh, Sung-Hee Ihm*, and Minhyung Lee* (2016) Peptide micelle-mediated cur cumin delivery for protection of islet beta-cells under hypoxia. J. Drug Target. 24(7): 618-623.
  13. Pureum Jeon, Manbok Choi, Jungju Oh, and Minhyung Lee (2015) Dexamethasone-conjugated polyamidoamine dendrimer for delivery of the heme oxygenase-1 gene into the ischemic brain. Macromol. Biosci. 15(7): 1021-1028.