Department of Bioengineering, Hanyang University


  1. Chunxian Piao, Gyeungyun Kim, Junkyu Ha, and Minhyung Lee (2019) Inhalable gene delivery system using a cationic RAGE-antagonist peptide for gene delivery to inflammatory lung cells. ACS Biomater. Sci. Eng. In press.
  2. Jungju Oh, Jaewon Lee, Chunxian Piao, Ji Hoon Jeong, and Minhyung Lee (2019) A self-assembled DNA-nanoparticel with a targeting peptide for hypoxia-inducible gene therapy of ischemic stroke. Biomater. Sci. 7(5): 2174-2190.
  3. Jin Sil Park, Seong-Ho Bae*, Subin Jung, Minhyung Lee, and Donghoon Choi* (2019) Enrichment of vascular endothelial growth factor secreting mesenchymal stroll cells enhances therapeutic angiogenesis in a mouse model of hind limb ischemia. Cytotherapy. 21(4): 433-443.
  4. Hanseul Park, Jungju Oh, Gayong Shim, Byounggook Cho, Yujung Chang, Siyoung Kim, Soonbong Baek, Hongwon Kim, Jeain Shin, Hwan Choi, Junsang Yoo, Junyeop Kim, Won Jun, Minhyung Lee, Christopher J Lengner, Yu-Kyoung Oh, and Jongpil Kim (2019) In vivo neuronal gene editing via CRISPR-Cas9 amphiphilic nano complexes alleviates deficits in mouse models of Alzheimer's disease. Nat. Neurosci. 22: 524-528.
  5. Jaewon Lee, Jungju Oh, Eun-song Lee, Young-Pil Kim, and Minhyung Lee (2019) Conjugation of prostate cancer-specific aptamers to polyethylene glycol-grafted polyethylenimine for enhanced gene delivery to prostate cancer cells. J. Ind. Eng. Chem. 73: 182-191.
  6. Gyeungyun Kim, Chunxian Piao, Jungju Oh, Minhyung Lee (2019) Combined delivery of cur cumin and the heme oxygenate-1 gene using cholesterol-conjugated polyamidoamine for anti-inflammatory therapy in acute lung injury. Phytomed. 56: 165-174.


  1. Dahee Lee, Eunji Choi, Jaewon Lee, Jungju Oh, Seonyeong Lee, Minhyung Lee (2018) RAGE-binding peptide-conjugated polyethylenimine as a dual-functional carrier: A RAGE-mediated gene carrier and an anti-angiogenic reagent. J. Ind. Eng. Chem. 67:284-292.
  2. Gyeungyun Kim, Chunxian Piao, Jungju Oh, and Minhyung Lee (2018) Self-assembled polymeric micelles for combined delivery of anti-inflammatory gene and drug to the lungs by inhalation. Nanoscale. 18: 8503-8514.
  3. Eunji Choi, Jungju Oh, Dahee Lee, Jaewon Lee, Xiaonan Tan, Minkyung Kim, Gyeungyun Kim, Chunxian Piao, and Minhyung Lee (2018) A ternary-complex of a suicide gene, a RAGE-binding peptide, and polyethylenimine as a gene delivery system with anti-tumor and anti-angiogenic dual effects in glioblastoma. J. Control. Release 279: 40-52.
  4. Seonyeong Lee, Chunxian Piao, Gyeungyun Kim, Ji Yeon Kim, Eunji Choi, and Minhyung Lee (2018) Production and application of HMGB1 derived recombinant RAGE-antagonist peptide for anti-inflammatory therapy in acute lung injury. Eur. J. Pharm. Sci. 114: 275-284.
  5. Xiaonan Tan, Gyeungyun Kim, Dahee Lee, Jungju Oh, Minkyung Kim, Chunxian Piao, Jaewon Lee, Min Sang Lee, Ji Hoon Jeong, and Minhyung Lee (2018) A curcumin-loaded polymeric micelle as a carrier of a microRNA-21 antisense-oligonucleotide for enhanced anti-tumor effects in a glioblastoma animal model. Biomater. Sci. 6: 407-417.
  6. Irfan Ullah#, Kunhho Chung#, Jungju Oh#, Jagadish Beloor, Sumin Bae, Sangah Clara Lee, Minhyung Lee, Priti Kumar*, Sang-Kyung Lee* (2018) Intranasal delivery of a Fas-blocking peptide attenuates Fas-mediated apoptosis in brain ischemia. Sci. Rep. 8:15041. (#Co-first authors)
  7. Subin Jung, Jung‑Hyun Kim, Changwhi Yim, Minhyung Lee, Hyo Jin Kang, and Donghoon Choi (2018) Therapeutic effects of a mesenchymal stem cell-based insulin-like growth factor-1/enhanced green fluorescent protein dual gene sorting system in a myocardial infarction rat model. Mol. Med. Rep. 18(6): 5563-5571.
  8. Yeomin Yun, Jinsoo Oh*, Yongbo Kim, Geewoo Kim, Minhyung Lee, and Yoon Ha* (2018) Safety and effectiveness of ex vivo gene therapy using neural stem cells combined with hypoxia/neuron-specific VEGF expression system in spinal cord injury model. Gene Ther. 25: 27-38.


  1. Jungju Oh, Min Sang Lee, Ji Hoon Jeong*, and Minhyung Lee* (2017) Deoxycholic Acid-Conjugated Polyethylenimine for Delivery of Heme Oxygenase-1 Gene in Rat Ischemic Stroke Model. J. Pharm. Sci. 106(12): 3524-3532.
  2. Minhyung Lee, Min Jun Kim, Jungju Oh, Chunxian Piao, Young-Woo Park, and Dong Yun Lee (2017) Gene delivery to pancreatic islets for effective transplantation in diabetic animal. J. Ind. Eng. Chem. 56: 45-54.
  3. Munhwan Choi, Jahyun Gu, Minhyung Lee*, and Taiyoun Rhim* (2017) A new combination therapy for asthma using dual function dexamethsone-conjugated polyethylenimine and vitamin D binding protein siRNA. Gene Ther. I24: 727-734.
  4. Md Nurunnabi, Seung-Ah Lee, Vishnu Revuri, Yong Hwa Hwang, Sung Hun Kang, Minhyung Lee, Sungpil Cho, Kwang Jae Cho, Younger Hyun, You Han Bae*, Dong Yun Lee*, and Yong-kyu Lee* (2017) Oral delivery of a therapeutic gene encoding glucagon-like peptide 1 to treat high fat diet-induced diabetes. J. Control. Release 268: 305-313.
  5. Ji Yeon Kim, Chunxian Piao, Gyeungyun Kim, Seonyeong Kim, Min Sang Lee, Ji Hoon Jeong, and Minhyung Lee* (2017) Combined delivery of a lipopolysaccharide-binding peptide and the heme oxygenase-1 gene using deoxycholic acid-conjugated polyethylenimine for the treatment of acute lung injury. Macrolmol. Biosci. 17(8). doi: 10.1002/mabi.201600490
  6. Chunxian Piao, Jeong Hyun Park, and Minhyung Lee* (2017) Anti-inflammatory therapeutic effect of adiponectin gene delivery using a polymeric carrier in an acute lung injury model. Pharm. Res. 34(7): 1517-1526.
  7. Eunji Choi, Jaesik Han, Xiaonan Tan, Jungju Oh, Dahee Lee, Taiyoun Rhim*, and Minhyung Lee* (2016) Combined delivery of temozolomide and the thymidine kinase gene for treatment of glioblastoma. J. Drug Target. 25(2): 156-162.
  8. Binna Oh, Hojung Song, Dahee Lee, Jungju Oh, Gyeungyun Kim, Sung-Hee Ihm*, and Minhyung Lee* (2016) Anti-cancer effect of R3V6 peptide-mediated delivery of an anti-microRNA-21 antisense-oligodeoxynucleotide in a glioblastoma animal model. J. Drug Target. 25(2): 132-139.
  9. Yong Hwa Hwang, Min Jun Kim, Yong-Kyu Lee, Minhyung Lee, and Dong Yun Lee* (2017) HMGB1 modulation in pancreatic islets using a cell-permeable A-box fragment. J. Control. Release 246: 155-163.


  1. Manbok Choi, Jungju Oh, Taiyoun Rhim*, and Minhyung Lee* (2016) Delivery of hypoxia-inducible heme oxygenase-1 gene for site-specific gene therapy in the ischemic stroke animal model. Pharm. Res. 33(9): 2250-2258.
  2. Ji Hyun Song, Ji Yeon Kim, Chunxian Piao, Seonyeong Lee, Bora Kim, Su Jeong Song, Joon Sig Choi, and Minhyung Lee (2016) Delivery of the high-mobility group box 1 box A peptide using heparin in the acute lung injury animal models. J. Control. Release 234: 33-40.
  3. Taiyoun Rhim and Minhyung Lee (2016) Targeted delivery of growth factors in ischemic stroke animal models. Exp. Opin. Drug Deliv. 13(5): 709-723.
  4. Jaesik Han, Jungju Oh, Sung-Hee Ihm*, and Minhyung Lee* (2016) Peptide micelle-mediated cur cumin delivery for protection of islet beta-cells under hypoxia. J. Drug Target. 24(7): 618-623.
  5. Manbok Choi, Ji Hoon Jeong, and Minhyung Lee (2016) Enhanced transfection efficiency of a cationic polymeric gene carrier using high mobility group box-1 box A peptide. J. Res. Institute Indust. Sci. 64: 59-64
  6. Dongkyu Kim, Sook Hee Ku, Hyusuk Kim, Ji Hoon Jeong, Minhyung Lee, Ick Chan Kwon, Donghoon Choi, and Sun Hwa Kim (2016) Simultaneous regulation of apoptotic gene silencing and angiogenic gene expression for myocardial infarction therapy: Single-carrier delivery of SHP-1 siRNA and VEGF-expressing pDNA. J. Control. Release 243: 182-194.
  7. Hye-Lan Lee, Hye Yeong Lee, Yeomin Yun, Jinsoo Oh, Lihua Che, Minhyung Lee, Yoon Ha (2016) Hypoxia-specific, VEGF-expressing neural stem cell therapy for safe and effective treatment of neuropathic pain. J. Control. Release 226: 21-34.